Lacosamide shows benefit in partial-onset seizures

March 8, 2010

By hammersmith

[Source: Modern Medicine] –  The use of lacosamide as an adjunctive treatment in patients with uncontrolled partial-onset seizures is effective in reducing seizure frequency and may provide additional benefits for some patients with secondarily generalized tonic-clonic seizures, according to research published online Jan. 27 in Epilepsia.

Steve Chung, M.D., of the Barrow Neurological Institute in Phoenix, and colleagues analyzed data from 405 patients, aged 16 to 70 years, who were taking one to three antiepileptic drugs but had uncontrolled partial-onset seizures. Subjects in this phase III trial were randomized to receive placebo or 400 or 600 mg of lacosamide daily. The study included an eight-week baseline period, a six-week titration period, and 12 weeks of maintenance.

For more information: Lacosamide Shows Benefit in Partial-Onset Seizures